Ketoconazole is one of the few proven and viable solutions to treat hair loss. Many people have heard of the Nizoral hair loss treatment as it is one of the most popular shampoos. Nizoral also comes in 1% and 2% ketoconazole options. Many hair loss websites will mention this as one of the big three treatments (including Propecia and minoxidil) because of the research done on its effectiveness.
On this page, we take a look at how ketoconazole works against hair loss and some of the clinical studies. Up first, we review some of the best products that contain ketoconazole, including the well-known Nizoral shampoo.
- 1 Top 10 Products with Ketoconazole
- 2 Best Shampoos with Ketoconazole for Hair Loss
- 3 What is Nizoral? What is Ketoconazole?
- 4 How Do Shampoos that Contain Ketoconazole Work?
- 5 Ketoconazole Studies and Research
- 6 Ketoconazole for Hair Loss: A Proven Method
- 7 How to Use a Ketoconazole Shampoo for Hair Loss
Top 10 Products with Ketoconazole
Here is our list of the top shampoos that contain ketoconazole in their list of ingredients. In our review section, we take a closer look at the 10 most popular products.
|Wick & Ström Premium Anti Hair Loss Shampoo||0.1% Ketoconazole, Aloe, Caffeine, Saw Palmetto, Niacin, Biotin, Mango Seed Butter||$1.25/Fl Oz|
|Nizoral AntiDandruff Shampoo||1% Ketoconazole||$1.60/Fl Oz|
|Signature Black Bottle Men's Anti-Hair Loss Shampoo||0.1% Ketoconazole, Caffeine, Biotin, Saw Palmetto, Niacin, Aloe||$1.50/Fl Oz|
|Revita Hair Growth Stimulating Shampoo||0.25% Ketoconazole, Apple polyphenol, Taurine, Caffeine, Carnitine, Emu Oil, Copper Peptides||$2.00/Fl Oz|
|Neugaine 3 in 1 Unisex Organic Hair Revitalizing Shampoo||1% Ketoconazole, Biotin, He Shou Wu, Argan Oil, Castor Oil, Saw Palmetto, Beta Sitosterol, Nettle, Green Tea||$2.20/Fl Oz|
|L'emarie Hair Growth & Hair Loss Shampoo||1% Ketoconazole, Aloe Vera, Wheat Proteins, Pumpkin Seed Oil, Caffeine, + More||$2.40/Fl Oz|
|Perfect Hair Regrowth Shampoo||1% Ketoconazole, Saw Palmetto, Emu Oil, Biotin, Salicylic Acid||$2.50/Fl Oz|
|Regenepure DR Shampoo, Hair, & Scalp Treatment||1% Ketoconazole, Saw Palmetto, Emu Oil, Niacin Vitamin B3, Caffeine, Vitamin B6, L-Pathenol, Linolenic Acid, Jojoba Oil, Zinc Oxide||$3.10/Fl Oz|
|Lipogaine Big 3 Hair Loss Shampoo for Men and Women||1% Ketoconazole, Copper Peptides, Biotin, Niacin, Wheat Proteins, Vitamin-B6, Zinc||$3.10/Fl Oz|
|Ultrax Labs Hair Surge Stimulating Shampoo||0.2% Ketoconazole, Niacin, Caffeine, Saw Palmetto||$7.50/Fl Oz|
Best Shampoos with Ketoconazole for Hair Loss
Here are our top 10 shampoos that made the cut. Each of these shampoos contains ketoconazole as an integral part of their formula. Nizoral for hair loss is one of the most common shampoo and scalp treatments with ketoconazole. If you’re in a hurry we suggest picking up a bottle of Nizoral hair loss treatment.
If you are looking for a straightforward ketoconazole shampoo, look no further. Nizoral for hair loss is one of the best shampoos to reduce dandruff and scalp DHT. It is a less expensive product and it does not contain the long list of ingredients that the other options have. It is a simple formula and its main active ingredient is the ketoconazole.
There are many theories on how exactly Nizoral combats hair loss, but it does three things simultaneously. It cleanses the scalp, its anti-fungal properties actively fight off fungus, and it also blocks androgen receptors (very similar to Topical Spironolactone). All three of these play a huge part in the most important factor of all: decreasing inflammation. While you certainly could use Spironolactone to achieve the same result, the fact that this can all be done in the shower with a shampoo formula makes it much more convenient for your daily routine.
Nizoral has been one of the most popular ketoconazole shampoos for quite some time and is available over the counter in a 1% solution. The only downside we have heard about Nizoral is that some folks experiencing rashes and skin irritation. This could possibly be due to the sodium lauryl sulfate Nizoral contains. Usually this chemical is not a problem but when you allow it to sit on your scalp for 5+ minutes that may cause some irritation and drying, especially with combined with ketoconazole (which in and of itself is quite a harsh ingredient). If you follow the instructions above you should be okay, but if you have extremely sensitive skin you may want to try one of the other options.
- Approximate Cost: $1.60/Fl Oz
- Instructions for Use: 2x/week
- Ketoconazole Content: 1% OTC, 2% w/ prescription
Lipogaine Big 3 is another excellent shampoo that does not include sodium lauryl sulfate. A further benefit of Lipogaine is that it is a volumizing shampoo, so it also makes the hair look great. It is cosmetically the best option if you are not going to supplement your ketoconazole shampoo with a conditioner or volumizer.
The ingredients line up in Big 3 is solid. Obviously it has ketoconazole, and as we know by now you can’t have an effective hair loss shampoo without ketoconazole. Copper peptides and biotin are also included, which are building blocks of hair and many people claim they help you hair grow stronger. It also contains niacin which increases blood flow to the scalp. Wheat proteins, Vitamin-B6, and Zinc are another essential part of Big 3 and have some clinical evidence that these three when used together reduce scalp DHT.
It contains the usual suspect ingredients saw palmetto, citric acid, nettle root extract, red clover which are usually included in herbal DHT blocker products. It is important to remember the jury is still out on these herbal ingredients and their efficacy when applied topically. There is still no hard evidence that they will block DHT, but certainly they couldn’t hurt. Many hair loss shampoo manufacturers include these ingredients in their shampoo as a marketing strategy, as without them in the mix they know the product won’t sell as well.
Lipogaine also included a handful of moisturizing ingredients. It contains emu oil, essential oils, and castor oil. This will help you maintain a moisturized scalp and prevent severe itchiness even after prolonged daily use.
- Approximate Cost: $3.10/Fl Oz
- Instructions for Use: 2-3x/week, Leave in 3-5 minutes before rinsing
- Ketoconazole Content: 1%
This is another excellent shampoo that has quite a few other ingredients thrown in. This shampoo does not include sodium lauryl sulfate. And it balances out the ketoconazole with ingredients such as emu oil and aloe vera which are great anti-inflammories. It is not marketed as an anti-dandruff shampoo, but it does contain 1% ketoconazole. Regenepure’s solution also includes saw palmetto which has in multiple clinical studies shown promise as a natural DHT blocker.
Other notables include niacin which improves blood flow to the scalp and salicylic acid which helps clear your pores of dirt and sebum. If you have a sensitive scalp, this is going to be a lot easier on it on your scalp. And while not clinically proven like ketoconzale, the other ingredients found in Regenpure have shown promise in a variety of independent studies.
Regenepure has taken the scattershot approach with their ingredients. These ingredients may or may not help but at the very worst they will help promote healthy Furthermore many of the ingredients have been shown to benefit the hair and promote healthy resilient hair follicles. The bottom line is your still purchasing this shampoo for the key ingredient which is ketacontazone, everything else is a side benefit.
- Approximate Cost: $3.10/Fl Oz
- Instructions for Use: Use Daily
- Ketoconazole Content: 1%
At first glance the ingredient list for Perfect Hair’s shampoo seems pretty impressive. And it is. However, this shampoo really has pretty mixed reviews, with quite a few resoundingly negative reviews. We have also read reports from folks who say the formula was watered down. If we give Perfect Hair the benefit of the doubt, perhaps they just had some bad batches when they first started manufacturing the formula.
From what it sounds like, Perfect Hair has upped their game since a few years ago. They built a new FDA compliant facility and are now manufacturing the product there. They back each batch and bottle with a quality guarantee. We still encourage you to err on the side of caution when ordering this product, but we think it is worth considering because of the price and robust ingredient list.
- Approximate Cost: $2.50/Fl Oz
- Instructions for Use: 2-3x/week, Leave in 3-5 minutes before rinsing
- Ketoconazole Content: 1%
Revita is a product by DS Laboratories that also contains ketoconazole. Many people love the cosmetic effect of Revita shampoo. The appearance factor always seems to be a point of emphasis with repeat users of Revita. We have an in-depth review of Revita if you are interested in this product. The downside to the product is that it is quite spendy.
- Approximate Cost: $2.00/Fl Oz
- Instructions for Use: Use at least 5x/week, Leave in 3-5 minutes before rinsing
- Ketoconazole Content: 0.25%
Wick & Ström is a salon quality hair loss shampoo, that’s made for all hair type, and for both men and women. The Ketoconazole within this particular product is rather low, but we don’t think that’s any reason to overlook it. On top of Ketoconazole, other active ingredients include caffeine and Biotin for follicle stimulation, Aloe Barbadensis Leaf for soothing and moisturizing, and Saw Palmetto Extract which blocks the enzyme that converts testosterone into DHT.
The bonus with this product, is that if you’re not satisfied with results after 60 days of continual use, the company will refund you the full amount for the product. However, with this perfect mix of vitamins and nutrients, Wick & Ström have made a solution to hair growth that we can get behind. The price is also extremely reasonable for the size and quality of product.
- Approximate Cost: $1.25/Fl Oz
- Instructions for Use: Use daily, massage into scalp and let sit for 2 minutes.
- Ketoconazole Content: (0.1%)
This particular Ketoconazole shampoo is made for men, and will prevent hair loss while simultaneously keep your hair healthy. You’ll be seeing results after using this shampoo for just a few weeks. The Biotin and Aloe in the mix will help clear toxins from your scalp and promote hair growth while the ketoconazole will do the rest of the heavy lifting. The price is also low, likely because the amount of ketoconazole is lower than many other suggested shampoos.
One of the ingredients that makes this product unique is the use of humulus, or as it’s known to the average beer drinker-hops! Research says that the combination of hops and caffeine can help with stimulation, in conjunction with the other active ingredients, this black bottle packs quite the punch.
- Approximate Cost: $1.50/Fl Oz
- Instructions for Use: Use daily, massage into scalp and let sit for 2-3 minutes.
- Ketoconazole Content: (0.1%)
This shampoo is on a different level than it’s competitors as it’s the only 100% Natural Base Anti-Hair Loss formula. It’s certified organic, and is boosted by Organic Argan Oil, and coconut oil. It’s sulfate free, with no parabens or chemical preservatives.
It’s safe for all types of hair, even color treated, since it is sulfate free. The big bottle is enough for a 3 month supply. If you don’t like it, you have 100 day money back guarantee, which is more than enough time to see how it will work with your hair. The price point is a bit higher, but that is to be expected with most organic products.
- Approximate Cost: $2.20/Fl Oz
- Instructions for Use: Use daily, massage into wet scalp for 1 minute, let it sit for 3-4 minutes.
- Ketoconazole Content: It should be noted that Neugaine recently changed their formula and no longer include Ketoconazole in their ingredients. However, we still recommend their product for hair loss and growth stimulation.
This is another 1% Ketoconazole shampoo that’s created for the hair of both men and women. It’s infused with multiple ingredients that can help eliminate DHT on the scalp and around follicles. L’emaire effectively cleans with a variety of oils including pumpkin see and tea tree oil. It’s scent free which makes it great for sensitive skins.
- Approximate Cost: $2.40/Fl Oz
- Instructions for Use: Use on for adults and children over the age of 12. Lather into wet hair and leave for 3-5 minutes. Only use every 3-4 days for up to 8 weeks.
- Ketoconazole Content: (1%)
This particular shampoo from Ultrax combines the power of Ketoconazole with the natural growth stimulation of caffeine, which has made it one of the top rated shampoos for hair regrowth stimulation of 2017. As mentioned before, caffeine blocks some of the effects of testosterone within the skin of the scalp. The biggest con of this one is definitely the price. However, the consumer ratings for it are off the chart, so you can trust that it’s worth the cost.
- Approximate Cost: $7.50/Fl Oz
- Instructions for Use: Massage and lather shampoo into scalp and leave for 2-5 minutes. Use 5 times per week for optimal result.
- Ketoconazole Content: (0.2%)
What is Nizoral? What is Ketoconazole?
Nizoral is a shampoo designed to help the user treat dandruff, hair loss, and other scalp conditions such as seborrheic dermatitis. Nizoral for hair loss is very effective because it contains ketoconazole. The popular Nizoral A-D hampoo contains 1% ketoconazole which is sufficient for scalp treatment and the reduction of follicular inflammation that contributes to hair loss. The topical forumlas of Nizoral for hair loss have not been associated with any adverse effects. Nizoral also comes in tablet form and actually has the potential to cause liver damage over sustained long term use. It is prescription only and used for anti-fungus purposes. Oral Nizoral hasn’t been shown to have any benefits for hair loss.
Ketoconazole is a synthetic antifungal drug. It used to be taken orally to treat a large number of fungal infections and in some cases is still used for this purpose. However less toxic options have become available in recent years. It has been discovered to aid in the battle against hair loss. It is an androgen receptor antagonist, meaning that it will compete against dihydrotestosterone to bind to androgen receptors in hair follicles. This competition is a good thing, the less DHT that binds to the follicles, the better. DHT damages hair follicles until they stop producing hair while ketoconazole has no such effect. Since Nizoral contains ketoconazole, it holds all the same benefits for hair loss sufferers.
How Do Shampoos that Contain Ketoconazole Work?
Many people get a little confused when first researching ketoconazole and its uses for hair loss and how it fits in the treatment picture. Ketoconazole comes in both pill and topical form. Ketoconazole tablets are used as an antifungal agent to treat a variety of skin infections although oral ketoconazole has no use in the treatment of hair loss.
Ketoconazole in shampoos primary use is to eliminate scalp conditions such as dandruff. It does this by killing fungi and yeasts that grow on the scalp through interfering with their cell membranes. Ketoconazole stops the fungi from producing ergosterol, which cell membranes need to survive. It is marketed as an antifungal pill for people with dandruff or a skin condition. However, this is not its only use. Ketoconazole for hair loss is an effective way to treat scalp DHT.
Ketoconazole Studies and Research
As mentioned, ketoconazole is one of the few hair loss treatment methods that is backed up with hard data. Ketoconazole has been fairly well studied and has many sources of documented results in its efficacy in preventing hair loss.
Here is a list of some of the more prominent studies:
- Khandpur et al, Journal of Dermatology, 2002. Find at US National Library of Medicine.
- Hair Loss Talk, 2012. Find at Vipadenievolos.
- Rafi and Katz, ISRN Dermatology, 2011. Find at US National Library of Medicine.
- Pieard-Francimont et al, Journal of Dermatology, 1998. Find at US National Library of Medicine.
- Aldhalimi et al, ISRN Pharmacology, 2014. Find at Hindawi Publishing Corporation.
Ketoconazole for Hair Loss: A Proven Method
A shampoo with ketoconazole must be a part of your regime. Without it, any other treatment you use will not be able to work optimally. Even when it comes to the tried and true Rogaine and Propecia, they too will work better on a scalp environment that is actively being treated with ketoconazole. So what is its application in regards to hair loss? Simply put, it is the only proven shampoo ingredient on the market that can help prevent or slow hair loss. Multiple studies have proven the effectiveness of ketoconazole as at the very least, a partial cure to hair loss.
Shampoos like Nizoral Hair Loss Anti-Dandruff Shampoo are uniquely able to help handle one of the important secondary cause of hair loss: inflammation. Inflammation is present in every person that is experiencing hair loss. The itchiness, tingling, and sometimes even intense pain and/or irritation are one of the hallmarks of hair loss in both men and women. If you have tingling or itching, your hair loss will progress that much faster and treatments you are using will not work as effectively.
One of the problems with ketoconazole is that it can leave the hair slightly lifeless and flat. It essentially nukes the scalp and kills off any fungus etc growing on the scalp. This can particularly problematic when you already have thinning hair and then you use a ketoconazole shampoo and it makes it appear even thinner. If your hair has really started to thin out, or even if you are just in the beginning stages of hair loss, you may want to consider purchasing a thickening conditioner/volumizer. You would use this conditioner after the ketoconazole as well as on your days off.
How to Use a Ketoconazole Shampoo for Hair Loss
There are 1% over-the-counter and 2% prescription ketoconazole solutions available. The 1% solutions are entirely sufficient for hair loss prevention. To maximize the benefit to your hair, you will want to use the shampoo once every three days (or twice a week on scheduled days) whatever is easiest for you to remember and create a habit for yourself.
- Apply the shampoo once as soon as you get into the shower and create a lather and massage into your hair and scalp for 1 minute.
- Rinse thoroughly and repeat, then leave the lather on for a minimum of an additional 3 minutes.
- Rinse off completely.